I want to enhance the dermal as well as systemic delivery of my compounds for the acceleration of wound healing by nanotechnology. But, I am not sure about the right approach. So, please tell me that formation of nanoparticles of my compounds is better or their Nanoencapsulation is better than the parent drug.
You feel a little confused on thetarget for the drug are you working on and about its delivery too. I would require a long study and discussion on both topics.
Hi,
One of the best systems for dermal / topical drug delivery is Transferosome (a special phospholipid-based carrier system which is ultradeformable and highly elastic vesicle).
Ref:
Transferosomes - A vesicular transdermal delivery system for ... - NCBI
https://www.ncbi.nlm.nih.gov › NCBI › Literature › PubMed Central (PMC)
by R Rajan - 2011
Hi,
Nanoencapsulation is simply the loading of a drug into a nanoparticle ... for your project and according to your drug physico-chemical properties (size, lipophilicity, effectiveness at small dose...) as well as cutaneous metabolism or degradation you may not need a nanocarrier to reach your goal (some potent API are absorbed into bloodstream from ointments or transdermal patches)
Best regards,
Hello sir,
That nanoparticles are matrix system in that drug is evenly distributed in the polymeric material and nanoencapsulation is the reservoir system in that drug is at the core region and polymeric material surrounds it. rate limiting steps in both system is release of drug from the polymeric system. so according to it select the formulation.
best regards,
Nidhi Raval
If your drug / bioactive compound is susceptible to degradation or loss of activity, of course it will be beneficial to employ encapsulation.
Can you please indicate the merits and demerits associated with these two approaches?
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