I have tried those 2 different routes with a hepatotoxic chemical and generated different results regarding liver damage in each case. Does it really make such a difference?
If the doses were same in both ip and oral, then there may be a difference in the bioavailability of the drug administered. You will have to check the bioavailability of the hepatotoxic chemical by both the routes. Mostly ip will have more bioavailability as it is administered directly into circulation. Oral dose will have to pass the barriers of absorption via stomach and then reach the circulation.