Binding constant and association constant with nano particles?
Dear Ahmed,
In my world, the binding constant refer to affinity, which is an equilibrium constant, whereas association constant, or rather rate, is how fast an association occurs. The affinity is related to the association rate as the ration between the dissociation- and association rate.
Kd= kd/ka or Ka=ka/kd,
where Kd is the reverse of Ka, both being the affinity, but depending in which discipline you work one or the other is the preferred choice. The affinity unit is in Molar or Molar-1. kd and ka are the dissociation- and association rate. kd is given in s-1 and ka M-1s-1
/Teodor
Dear Ahmed,
In my world, the binding constant refer to affinity, which is an equilibrium constant, whereas association constant, or rather rate, is how fast an association occurs. The affinity is related to the association rate as the ration between the dissociation- and association rate.
Kd= kd/ka or Ka=ka/kd,
where Kd is the reverse of Ka, both being the affinity, but depending in which discipline you work one or the other is the preferred choice. The affinity unit is in Molar or Molar-1. kd and ka are the dissociation- and association rate. kd is given in s-1 and ka M-1s-1
/Teodor
As I understand, both are same. I will keep following this question to educate myself, if difference occurs, if any? Thanks
see
https://ocw.mit.edu/courses/biology/7-51-graduate-biochemistry-fall-2001/lecture-notes/fa01lec07.pdf
to avoid confusing K and k and Ka andKd
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