Rosai Dorfman's disease is the accumulation of histicytes in lymph nodes and sometimes in extra nodal regions of the human body. Treatment depends on the presenting symptoms, patient clinical state at presentation and the organ involvement. It may not require any treatment other than observation, sometimes may require surgery for airway divertion, may require the use of prednisolone or chemoradiation. I would like to know the current management of this disease besides those just mentioned above.
Dear Ogah from dermatological point of view
Rosai-Dorfman Disease, also called sinus histiocytosis with massive lymphadenopathy, is a non-Langerhans histiocytic disease. The skin is the most common extranodal site, occurs in older females and presents in various forms, ranging from single papules to multiple nodules and plaques. Infiltration of the dermis or subcutaneous tissue with associated sclerosis and composed predominantly of epithelioid histiocytes with a pale to eosinophilic cytoplasm. The hallmark of Rosai-Dorfman disease is emperipolesis, in which lymphocytes and other inflammatory cells reside undisturbed within the cytoplasm of the histiocytes. Plasma cells are frequently dense in cutaneous Rosai-Dorfman disease. Histiocytes show positive staining for CD68 and S-100 in Rosai-Dorfman disease. CD1A is negative. Rosai-Dorfman disease must be differentiated from Langerhans cell histiocytosis, Reticulohistiocytoma and Juvenile xanthogranuloma. Spontaneous remission within months or a few years so many individuals will not require therapy. In more serious cases, treatment options have included steroids (e.g., prednisone), alfa-interferon, chemotherapy and radiation therapy.
Sub mentioned paper my offer some help is some way, hope so:
Bashir A. H. H.1,2*, Lamyaa A. M.2 and Al Hassan A. M.2. Langerhans cell histiocytosis (LCH) associated with Helicobacter pylori infection. Clinical Reviews and Opinions Vol. 3(4), pp. 45-50, June 2011.
Available online http://www.academicjournals.org/cro
Dear Bashir,
Thank you so much for the answer given to my question on RDD which is appreciated greatly.
My kind regards.
Dr. Ogah
J Otolaryngol Head Neck Surg. 2008 Apr;37(2):E49-54.
[Paranasal sinus localization of Rosai Dorfman disease: long-term evolution and importance of magnetic resonance imaging].
[Article in French]
Daoud R1, Malinvaud D, Meatchi T, Rahman HA, Halimi P, Bonfils P.
- Badges
- Science topic