In the attempt to do better research innovative experts often cross the lines of established knowledge strongly supported by academic authorities. However, it appears sometimes necessary to find novelty even in the way research is conducted. In some circumstances, people with less knowledge in a specific field could lead to improvement of knowledge in this field.
I am looking to cases where researchers have improved available knowledge proceeding outside the box.
This question is in line with the ideas developed by Waine C. Booth, Gregory G Colomb and Joseph M. Williams in the book "The Craft of Research."