Basically you have 2 kinds of phosphatase in serum: alkaline and acid.
Alkaline phosphatases are a reflection of liver health, bone remodeling or the presence of a fetus.
Acid phosphatases are associated with prostate.
Regarding intracelular phosphatases, critical for insulin action for instance, I do not know of any drugs that modify them. Altering their functon in a non specific way would have dire consequences in signalling.
Thank you Alejandro, that's very interesting. So I guess that alkaline phosphatases could be regulated by hormones. Do you have an idea if intracellular phosphatases could also be regulates by hormones such as estrogens and/or progestogens?
Alk PO4ases are regulated by PTH and vit D. I am sure that most likely intracellular PO4ases that participate in signaling (there should be many, many Po4ases in the cell) have regulation by most hormones.