A simple question, perhaps badly phrased in the title, what is the largest singular biomolecule i.e., not stacks of carbohydrates one after the other, to be involved in post-translation modified amino acids?
For example, lipidation could add up to 50-60 atoms to a side chain of a protein. Glucose can break down and form a crosslink between lysine and arginine or between two lysines, essentially adding an addition 15-20 atoms to the protein.
Thanks
Anthony
Here is a long list of known post-translational modifications.
https://en.wikipedia.org/wiki/Post-translational_modification
Probably the largest non-carbohydrate modification is the covalent attachment of another protein, such as ubiquitin (8.5 kDa) SUMO (12 kDa), and ISG15 (17 kDa).
Here is a long list of known post-translational modifications.
https://en.wikipedia.org/wiki/Post-translational_modification
Probably the largest non-carbohydrate modification is the covalent attachment of another protein, such as ubiquitin (8.5 kDa) SUMO (12 kDa), and ISG15 (17 kDa).
Poly-ubiquitination may be the largest post-translational midification.
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