Hello all,

I have a huge dataset of longitudinal medical records. Each record contains indications for drug and disease. I have been able to calculate the Cure Rate in the population given a particular drug. This is, simply 1 minus the ratio of number of diseases after the number of diseases before the drug.

Unfortunately, this calculation would suggest that every drug I am interested in has a poor level of medical efficacy. Clearly, this is because the drugs I am interested in might only work on a subset of patients, therefore, a complete population based study is going to be very biased.

Given how many patients show a reduction in disease after taking the drug, how can I determine whether that was statistical significant or just by chance?

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