We are looking for potential MSS as well as MSI that clinically resembles CRC. The APCmin mice look promising but many develop, particularly in the small intestine and resemble FAP.
Article Mouse models for colorectal cancer
https://www.croh-online.com/article/S1040-8428(15)30058-5/pdf
Article Mouse models of colorectal cancer as preclinical models
Hi, thanks for the articles. I had read those but it is hard to know which best molecularly represents CRC in patients as many are small intestinal.
Also, we are looking at immunotherapy and the APC mice have hematopoietic defects. I was wondering if anyone has any personal experiences or preferences. These models and this type of cancer are new to me.
Colorectal cancer (CRC) is the third leading cause of cancer-related death in the United States, with the number of affected people increasing. There are many risk factors that increase CRC risk, including family or personal history of CRC, smoking, consumption of red meat, obesity, and alcohol consumption. Conversely, increased screening, maintaining healthy body weight, not smoking, and limiting intake of red meat are all associated with reduced CRC morbidity and mortality. Mouse models of CRC were first used in 1928 and have played an important role in understanding CRC biology and treatment and have long been instrumental in clarifying the pathobiology of CRC formation and inhibition. This review focuses on advancements in modeling CRC in mice.
Animal models of human colorectal cancer: Current status,
uses and limitations
Vijay K Mittal, Jasneet Singh Bhullar, Kumar Jayant
Review article
From mice to men: Murine models of colorectal cancer for use in
translational research
Spontaneous initiation, promotion and progression of
colorectal cancer in the novel A/J Min/1 mouse
Sporadic colon cancer murine models demonstrate the value of autoantibody detection for preclinical cancer diagnosis