What is the best route to synthesize fisher's base (1,3,3-Trimethyl-2-methyleneindoline) ?

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Talaat I. El-Emary

The following links, beside the attached paper may be helpful for you.

https://www.google.com.eg/url?sa=t&rct=j&q=&esrc=s&source=web&cd=2&cad=rja&uact=8&ved=0ahUKEwijsJSX2KzMAhWGOxoKHWjND84QFgghMAE&url=http%3A%2F%2Fwww.google.com%2Fpatents%2FEP1535968A2%3Fcl%3Den&usg=AFQjCNEIu-DuyZeHgyuxbYD4POgsOUC3fA

https://www.google.com.eg/url?sa=t&rct=j&q=&esrc=s&source=web&cd=3&cad=rja&uact=8&ved=0ahUKEwijsJSX2KzMAhWGOxoKHWjND84QFggkMAI&url=https%3A%2F%2Fwww.google.com%2Fpatents%2FUS20050113546&usg=AFQjCNE3DT48OBOs3HABnJulDY1br7I4MA

William Harter

The material is commercially available from Sigma-Aldrich and not very expensive. It may be more cost effective to just buy it. catalog M46209 - 1,3,3-Trimethyl-2-methyleneindoline

Bruce Levison

You should check other suppliers besides Sigma-Aldrich such as Alfa Aesar A16741 1,3,3-Trimethyl-2-methyleneindoline, 95% 250grams for $82.24 USD or Acros Organics 421942500 1,3,3-Trimethyl-2-methyleneindoline, Fischers base, 98.5%, 250 GR, $95.77 USD. Use a search engine like Chemexper https://www.chemexper.com to search for an inexpensive local source for the chemical.