Description of the systemic administration of PMA (phorbol 12-myristate 13-acetate) in mice:

As a protein kinase C (PKC) activator, the phorbol ester compound PMA is often used to build inflammation and related disease models in in vivo studies. The high-purity PMA (≥99% HPLC purity; Cat.No.: HY-18739) and professional technical support provided by MCE (MedChemExpress) can help optimize the design of experimental plans.

According to the literature data integrated by the MCE bioinformatics team, Phorbol 12-myristate 13-acetate (PMA) can be used to induce ear edema models and foot edema models in mice. The relevant induction scheme and experimental details can be viewed through the following link:

https://www.medchemexpress.com/Phorbol-12-myristate-13-acetate.html

Moreover, PMA (Cat.No.: HY-18739) has been verified by MCE system biology: at a concentration gradient of 100 ng/mL and 200 ng/mL, treatment for 24 hours and 48 hours can effectively induce THP-1 cells to differentiate into macrophage-like cells.

Experiment Findings [Finding] Phorbol 12-myristate 13-acetate (PMA) Induces Diff...

• DOI:10.13140/RG.2.2.23477.79845

For more experimental details, please contact the MCE technical team for professional after-sales answers.

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