What is the best molecular marker to separate healthy and pathological astrocytes?

07 September 2017 1 6K Report

I have quantified astrocytes with GFAP in a series of westerns. I would like to know if the lower level of GFAP I am seeing is because it is non-reactive due to a healthy environment or non-reactive due to inability to signal an inflammatory response and therefore, pathological. I would not like to do a morphological analysis at this point. I was more looking for a molecular marker.

Thanks in advance!

Nuzhat Husain

Neoplastic astrocytes in diffuse low grade gliomas frequently express IDH1.

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