We are trying to quantify vitamin B12 in pharmaceuticals indirectly by the quantification of cobalt ( which is present in vitamin B12). We may use the solid sampling technique. Any suggestion for the best modifier to be used.
Palladium gives a very good result, about 0.15ug/L detection limit is possible. At a pyrolysis temperature of above 1400 oC, you may have no need for a modifier. Your may have to replace your tube more frequently. This may help you
https://www.researchgate.net/publication/222689573_Determination_of_cobalt_in_biological_samples_by_line-source_and_high-resolution_continuum_source_graphite_furnace_atomic_absorption_spectrometry_using_solid_sampling_or_alkaline_treatment
Article Determination of Cobalt in Biological Samples by Line-source...
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