I want to generate a graph showing the relative evolutionary constraints on single positions of a certain sequence of amino-acids (protein sequence).

I came across this attached figure of E.V. Koonin in his book "The Logic of Chance", what he called "genomescape", is there any method to measure evolutionary constraints per residue in a sequence of amino acids, and generate such a graph?

Thanks

More Abdalla G. Alia's questions See All
Similar questions and discussions