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Questions related from Jan Zaucha
For breast, ovarian and colon CPTAC analyzed TCGA samples. Where can I find a mapping between CPTAC IDs and TCGA barcodes?
05 June 2023 8,789 1 View
I have a RNA-seq dataset without controls (or you can consider them all controls) and I am interested in an unsupervised ranking or clustering of samples with regard to how they are expressing...
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Hello everyone, I've recently updated MS Word on my Mac. I now have version 2016, before I had 2011. But the Mendeley plugin is gone and I've not had any luck trying to recover it. I've...
18 March 2020 5,316 4 View
The minimum free energy of an RNA secondary structure is generally said to correspond to the energy lost due to nucleotide base pairing. Therefore I cannot see the difference between two sequences...
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It is clear that hypo/hyper methylation affects gene expression. However, it is not the only source of transcriptional variation. How can I estimate the amount of transcriptional variation that...
08 December 2017 3,580 5 View
Phylogenomic tree branch lengths are expressed in units of 'average substitution rate' (number of substitutions per site). Now, we can have substitution of amino-acids or nucleotides. Protein...
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The catalytic active sites of many proteins harbor ions. I often read the ions are essential for the catalytic activity. Can someone explain how the presence of the ion confers the catalytic...
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