What is the best method to convert chloroactic acid (ClCH2COOH) into chloroacetic anhydride (ClCH2CO-O-CO-CH2Cl)?
I am agree with Theo Nikiforov ,even acid chloride will be the best method for the synthesis of anhydride in my view. You can use SOCl2 or Oxalyl chloride(mild condition) for making acid chloride.
thanks for the advice, I will try use acid chloride instead.
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For further information please see the attached figure.
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