reactions are usually catalyzed by bases such as ammonia, ethylenediamine,
guanidine, dimethylamino pyridine, piperidine or corresponding piperidine salt, Lewis acids in organic solvents and ionic liquids have also been added to the existing list of substances that assisted Knoevenagel condensation in organic synthesis. a grinding method under solvent free conditions used in Knoevenagel condensation has rapidly increased. Many catalysts have been used in the synthetic procedure, for example , K2O-Al2O3, CaO, ZnCl2, NH4OAC and triethyl benzyl ammonium chloride (TEBA). Knoevenagel reaction under solvent - free conditions carried out by microwave irradiation and by grinding has rapidly increased.But microwave irradiation processis difficult to apply in the industrial process until now and the grinding reaction is only suitable to some active solid reactants