I want to study aneurysm growth (in volume) in a set of subjects, based on Time of Flight images (MR) images at two time points.

For each subject, I want to do a rigid registration between time of flight images as well as a segmentation of the cerebral vascular system. And then, I want to compare the two registered segmentation volumes in order to quantify the aneurysm growth.

For doing this, some teams used in-house registration tools (not distributed as far as I know, AnToNIA for ex) and the registration is performed using a volume of interest around the aneurysm sac (and not using the whole brain).

I currently know free registration tools not specific to aneurysms (FLIRT of FSL for exemple: http://fsl.fmrib.ox.ac.uk/fsl/fslwiki/FLIRT). Additional question: Do you think these kind of methods is appropriate to do "aneurysms registration" ? 

Thanks in advance,