We have working on depression treatment with transcranial magnetic stimulation. We have different measures like cordance of prefrontal lobe electrode, power density, theta band power spectrum etc. If anyone has experience in assessing the correlation between antidepressant effects and QEEG measures, please advise me in this case.
Ali, we recently published on this in a sample of 90 MDD patients, and mainly focused on predicting non-response. The most promising metrics we found to be associated with non-response were: 1) Slow alpha peak frequency (mainly frontal, and make sure to inspect the 7-13 Hz range); 2) Increased frontal theta activity and 3) An increased P300 amplitude at Pz (exceeding 20 uV).
I also think that looking at connectivity between areas (e.g. DLPFC-ACC) could yield valuable insights. For example we also looked at 30 responders to treatment pre- and post-treatment and don't find strong changes in EEG power or ERP's on a group level. However, we did see highly significant increases in connectivity in several frontal to ACC networks from pre- to post-treatment (we're planning to publish this soon). You can find more details in: Arns M, Drinkenburg WHIM, Fitzgerald PB, Kenemans JL. Neurophysiological predictors of non-response to rtms in depression. Brain Stimul 2012;5:569-76.
Dear Arns
Thanks for the valuable comments. As your results indicated to build a reliable biomarkers for EEG response to the treatment agents we should use non-linear measures. I will read your paper and get back you in case of any questions. Thanks again for the guide
Hello Ali,
We are currently looking into this, please get in touch if you'd like to chat. [email protected]
Best regards,
Fidel
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