Do you mean therapeutics target for drug development? Some enzymes, anti-glycation.....
Thank you for the question.
These are the 2014 ADA guidelines:
Glycemic Goals in Adults
Recommendations
- Lowering HbA1C to below or around 7% has been shown to reduce micro-vascular complications of diabetes and, if implemented soon after the diagnosis of diabetes, is associated with long-term reduction in macro-vascular disease. Therefore, a reasonable HbA1C goal for many nonpregnant adults is
Reasonable goals are HbA1c below 7%, normal total cholesterol levels and blood pressure within normal values
Here are the ADA recommendations, I hope you find them useful!
http://care.diabetesjournals.org/content/37/Supplement_1/S14.full.pdf+html
Dear SushilKumar:
if you are not understading leave it or learn from others, the question is that
what is the best therauptic target, if any body is working in drug development area, easily they can understand.
Regards
Venkatesham
Dear Venkatesham
All targets are important. I think diabetes is not a disease to treat a particular target. Because it is a metabolic disorder. The current level of allopathy treatment is a temporary solution. We need the components which act on most of the targets. it is possible with our traditional way of treatment. We have lots of medicinal plants with proper proportion (polyherbal) to cure diabetes. Each and every medicinal plants of the polyherbal will take care of most of the targets (i.e. Antioxidants, Insulin mimic effect, Insulin secretory effect, PPAR agonist, glucosidase & amylase inhibition, etc).
In the diabetes type II associate to the obesity, in my opinion, the best objective marker is the weigth.
If you loss kilos, the insulinoresistance go in down, the hemoglobin glycated go to the normal range, the lipidic profile go to normal numbers, etc.
All that is possible when you make a treatment with "protein diet": VLCD but not animal protein; minerals and vitamin supplied and , too, protein with high biological value at 1,2-1,5 g / kg ideal/ day supplied.
In my opnion: the objective is a go to the normal weigth.
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