What is the best concentration of NaOH for CIP process in pharmaceutical industry?

30 September 2024 1 7K Report

Please kindly let me know which concentration of NaOH is okay for the CIP of mobile vessels and pipes when we want to eliminate bacterial endotoxins or bacterial species

Abdelhak Maghchiche

For CIP processes to eliminate bacterial endotoxins or species in mobile vessels and pipes, a sodium hydroxide (NaOH) concentration of 0.5% to 2% is recommended, with some applications using up to 4%. Operating at temperatures between 60°C to 65°C enhances cleaning effectiveness.

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