Almitrine-Raubasine combination effectively increases both arterial oxygen partial pressure and it is known as effective O2 supplier. However, what is the actual mechanism of these two components separately or in combination.
I will highly appreciate your suggestion on this regard. (Pathophysiology, pharmacology, pharmacokinetics ......etc....)
Hi,
almitrine enhances respiration by acting as an agonist of peripheral chemoreceptors located on the carotid bodies. The drug increases arterial oxygen tension while decreasing arterial carbon dioxide tension in patients with chronic obstructive pulmonary disease. It may also prove useful in the treatment of nocturnal oxygen desaturation without impairing the quality of sleep;
raubasine acts as a α1-adrenergic receptor antagonist with preferential actions over α2-adrenergic receptors
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