Various oxidant products are continuously generate in body which can be neutralize by antioxidant. ROS and RNS are vary reactive to various protein structure and disturb its normal function... which leads to AGEs and accumulated in different organs leads to various complication in diabetes...We need to search such antiglycated agent which can inhibits this

Basically mitochondrial damage happened with these reactive oxygen species, its really continuous change, please send some articles.

I am answering the first part of the question of Mr. Malik: What is Reactive Oxygen Species.

Various compounds, superoxide, nitrogen monoxide, hydroxyl radical, peroxynitrite, etc. are now known as ROS. This is very unfortunate, because these species all have very different reactivities. For instance, NO does very little: it binds to Fe(II) and reacts rapidly with superoxide. Superoxide does not react with any amino acids, with the possible exception of cysteine (but that is a slow reaction). The hydroxyl radical reacts very rapidly with nearly every biomolecule, and so on. Peroxynitrous acid hydroxylates (often forgotten) and nitrates tyr and trp, aside from other reactions. For all of these species you have to look at the product of the rate constant and the concentration of the target.

Many of the compounds known as ROS have been studied decades ago by radiation chemists. The abbreviation ROS has caused confusion and should not be used. The present state of confusion has not been helped by many fluorescent assays that claim to be specific for a particular "ROS", but are not.

What Mr. Malik should do is read review articles on these species. You can begin with the papers attached below, but older papers on superoxide, hydrogen peroxide and hydroxyl are still useful.

Good luck!

Its excellent explanation and background of the reaction, i appreciate, i further study these papers, if any hesitation will ask from you, thanks a lot sir,