For example, are metabolically important genes regulated by low concentrations of oxidants (e.g. hydrogen peroxide)?
The task involves predicting a binary outcome in a small data set (sample sizes of 20-70) using many (>100) variables as potential predictors. The main problem is that the number of predictors...
10 November 2015 9,194 11 View
For example, cells were exposed to different concentrations of a toxic chemical. Two types of data were measured: (1) the critical concentration above which no cell growth occurred, (2) for lower...
03 April 2015 5,053 24 View
The data provided are percentiles (median, 75th and 90th) from several histograms. The number of observations comprising each histogram is known. The shape of the data distribution in each...
31 December 2014 6,905 5 View
Suppose a mouse study is being designed which aims to address the question of which dose response shape (e.g. linear, quadratic, exponential, etc) best describes the response to a particular...
04 May 2014 3,089 11 View
Some in vitro data using cancer cell lines has been published, which suggests reprogramming of non-tumorigenic cancer cells to cancer stem cells induced by ionizing radiation. Is there some...
03 April 2014 6,328 1 View
Suppose a mathematical model consisting of a system of differential equations is constructed to describe some biological phenomena. Analytic solutions are not available - only numerical ones. Are...
03 April 2014 476 14 View
For example, suppose a certain method was chosen for power/sample size calculation for a future experiment, with the intent to use the same method to analyze the experimental data. But the...
31 December 2013 5,384 20 View
Among the many available methods, which are the most efficient (i.e. require the smallest sample size for defined alpha and beta) and relatively straightforward to implement?
11 December 2013 9,901 10 View
Suppose there are several treatment groups. Within each group there are exponentially distributed data, i.e. the number of counts is proportional to exp[-A*x^B], where A and B are parameters. What...
09 October 2013 389 56 View
Suppose a non-linear smooth function is fitted to some data (e.g. means and standard errors for cell survival after various radiation doses). What are some useful ways to assess goodness of fit...
08 September 2013 7,926 39 View
Question to you and THEM, the New Journal, "Integrative Psychological and Behavioral Science" -- do you not know, and have you not seen, this done before? There appears to be a core problem for...
02 March 2021 3,024 2 View
Could you please recommend some good journal that accept very long revie papers (approximately 6000+ words) in neurosurgery, cancer biology ?
01 March 2021 8,087 3 View
Dear Dr. Cai, my name is Simone Prospero and I work in the team of Phytopathology at the Swiss Federal Institute for Forest Snow and Landscape Research (WSL;...
01 March 2021 1,133 1 View
Incompletely cross-linked pdms are difficult to remove.
01 March 2021 798 3 View
Also when RHAMM binds hyaluronic acid, they get internalized, will RHAMM also be degraded? Or both CD44 and RHAMM will be transferred back to the cell membrane? Asking for breast cancer cell line...
01 March 2021 8,169 2 View
Hi, I'm looking for data (mainly related to management: growth rate, canopy size, soil and climate preferences, etc.) about tropical trees used in tropical agroforestry. Have you ever heard about...
28 February 2021 7,356 8 View
Is the period to autoclave not enough? The inoculation in a hood and flame and UV and alcohol.
27 February 2021 9,356 3 View
What is the most suitable medium of ascomycetes fungi ??
26 February 2021 4,413 1 View
Hi everyone, Illumina provides a list of primers to amplify with high taxonomic coverage the ITS1 region for further fungal sequencing, but I cannot find the exact amount necessary of each...
25 February 2021 6,969 3 View
Hi Everyone, Has anyone here worked with MPC cell line? Any tips or tricks? I am just venturing into cell biology and any advice on this topic would be highly appreciated. Thank you so much. Niusha
22 February 2021 3,891 2 View