Drugs which inhibit the enzyme cholinesterase and so increase the cholinergic activity are called Anti-cholinesterase
Anti-ChE inhibits the enzyme cholinesterase.
Prevents hydrolysis of acetylcholine .
Increase acetylcholine concentration at cholinergic drugs sites.
So, Anti-ChE are called indirectly acting cholinergic drugs.
I ask you to see my articles and monographs in RG, you will find the answer to your question.
https://www.researchgate.net/profile/PF_Zabrodskii/research
Article P. F. Zabrodskii, V. V. Maslyakov, and M. S. Gromov. THE INF...
Article The influence of organophosphorus compound dimethyldichlorov...
Article Role of α7-Nicotinic Acetylcholine Receptors of B Cells in t...
Article P.F. Zabrodskii, V.V. Maslyakov, M.S. Gromov. Mechanisms of ...
Malathion
Book P.F. Zabrodskii. Immunotoxicology of organophosphorus compou...
Article Mechanisms of immunotropic effects of organophosphorus compounds
Article Mechanism of Suppression of Phagocytic and Metabolic Activit...
(Russian VX, and sarin
Article Bulletin of Experimental Biology and Medicine 12/2013; 156(1...
Article Disturbances of immune status and cytokine profile caused by...
Experiments on noninbred rats showed that the chronic intoxication with organophosphorus compounds sarin and methylparathion (30 days; total dose, 0.9 LD50; single daily dose, 0.03 mg/kg,) significantly decreases the immune responses and reduces the concentrations of blood cytokines IFN-gamma, IL-2, IL-4, IL-6, and IL-10. The damage is more pronounced in Th1 cells than in Th2 lymphocytes. The administration of imunofan (single daily dose, 20 microg/kg) for 5 days partly recovers the immune status and the content of cytokines in the blood.
Article Disturbances of immune status and cytokine profile caused by...
Experiments on noninbred rats showed that the chronic intoxication with organophosphorus compounds sarin and methylparathion (30 days; total dose, 0.9 LD50; single daily dose, 0.03 mg/kg,) significantly decreases the immune responses and reduces the concentrations of blood cytokines IFN-gamma, IL-2, IL-4, IL-6, and IL-10. The damage is more pronounced in Th1 cells than in Th2 lymphocytes. The administration of imunofan (single daily dose, 20 microg/kg) for 5 days partly recovers the immune status and the content of cytokines in the blood.
Dear prof. P.F. Zabrodskii
It's very useful research articles, thank you
Best regards
Houda
Dear All, Please help me below the following the questions:
After a first cycle, there are 2 copies of DNA, but they are not correct length DNA.
It means that they contains DNA regions which you do not want to amplify.
Then, when (how many cycles) does correct length DNA appear?
Correct length DNA means that amplified DNA only contains DNA region which is sandwiched between two primers.
And how the numbers of incorrect length DNA and correct one increase with each cycle?
Q2.
Annealing temperature is one of the most important factors to amplify a proper DNA region.
What is important to decide annealing temperature?
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