In the past, we have used DE52 as a pre-column to Ni-NTA to aid in removal of unwanted contaminants like DNA..
Is there another product that will achieve this since DE52 is now discontinued?
how about DEAE- sepharose CL-6B. it is also a weak anion exchange resin using DEAE linked to sepharose instead of linked to cellulose. You can find it at Sigma.
You can use DEAE-Sephacel from Sigma. It has the same behavior than DE52.
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