Hello,
which tool would you suggest for assess of RoB of the uncontrolled interventional before-after studies. There are such kinds of clinical trials, in which the participants are checked before employing the intervention as there is no separate control group. They are also checked after applying the intervention.
As ROBINS-I is designed to be used for the controlled studies like nRCTs and NOS is proper for the cohort and case studies (cohort is a non-interventional study (observational)) and unfortunately NIH is not a standard and official tool, which tool would you suggest?
Thanks in Advance, Gelareh
Hi,
If there is a pre and post-intervention only, then the paired t-test is applicable.
Hi Gelareh,
I encountered a similar problem in one of my studies. The solution to this is to use NIH tool for quality assessment. If you google this, you will find not only a tool for uncontrolled before after studies but also tools for other types of studies as well on the same site. This is an acceptable tool since I found studies in high impact factor journals like JAMA that had used this tool. Hope this answers your question.
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