Good morning.

I am doing a drug release trial targeting the small intestine. I use a system where I change the release buffer at each sampling. So I get the cumulative percentage release. Two hours after starting the test (the time it remains in the stomach) I have a 20% release of the drug and, 24 hours later a 100% release.

My question is.. What is a maximum percentage of drug accumulated for the stomach (2 hours) to be considered good and what is the maximum time at which I must obtain 100% drug release.

Could you leave me the references of your answers please. Thank you very much for your time.