High-fat-diet (HFD)-induced obesity is a major contributor to diabetes and cardiovascular disease, but the underlying genetic mechanisms are poorly understood .
And none of these papers discussed any diet recipies: ?
RNA-Sequencing of Drosophila melanogaster Head Tissue on High Sugar and High Fat Diets: http://www.g3journal.org/content/early/2017/11/15/g3.117.300397
Systems Genomics of Metabolic Phenotypes in Wild-Type Drosophila melanogaster:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4063932/
Exploring Effects of Sex and Diet on Drosophila melanogaster Head Gene Expression : http://www.jgenomics.com/v05p0128.htm
yes Sir, there has been no explanation of any diet recipes
thanks you very much for putting links to these papers .
The composition of so-called "high fat" Drosophila diets is not fully defined in the scientific literature which complicates comparison of experimental data between labs. In some studies lard (e.g., 15 %) is used to induce obesity whereas is other studies coconut oil (20-30%) is administered.
A consensus needs to be reached to better standardize the composition of experimental Drosophila diets for nutritional studies (see Lüersen et al. Genes & Nutrition 2019; 14:3)
Hi Gerald
I don't work with Drosophila, but I would think that a diet rich in the saturated fatty acids present in yeast would be the way to go. Considering that yeast is rich in 16:0 and 18:0, a source rich in those fatty acids (like lard) maybe would be a better option than the coconut oil, which is rich in the medium chain fatty acids (6 to 12:0).
Best wishes
Noemi
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