I submitted an article 21 months ago. The handling editor acknowledged the receipt within two weeks. After nine month, I asked the status of my article and I received reply after three days that the article is still under review process. After eighteen months, I asked the status again but this time I did not receive any reply. Then I sent a gentle reminder after 20 months, but still I did not receive any reply. At this stage, what can/should I do? Obviously many researchers will be facing (or have faced) this situation. Some advice/suggestion in this regard will be gratefully acknowledged.