What happens in the caregiver's brain when he/she uses substances or alcohol?

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s. Béatrice Marianne Ewalds-Kvist

The abuse of alcohol is eating up the ventricles in the brain (regardless of profession) so they get bigger and bigger and nerve cells are lost on the "shores of the seas".

Giulia Perasso

Dear, this is so interesting. Could you please suggest me scientific papers about it?