Insulin resistance is considered as an important contributor, if not he sole cause of PCOS. But i believe there must be other tangible factors which cause insulin resistance. There are features of ladies and young girls which have all features of PCOS but no insulin resistance. Yes congenital adrenal hyperplasia can be one but still there are patients with PCOS like symptoms but no insulin resistance.
So what else can cause such features?
PCOS is a “syndrome,” or group of symptoms that affects the ovaries and ovulation. Its three main features are:
cysts in the ovaries
high levels of male hormones
irregular or skipped periods.
The lack of ovulation alters levels of estrogen, progesterone, FSH, and LH. Estrogen and progesterone levels are lower than usual, while androgen levels are higher than normal.
Genes, insulin resistance, and inflammation have all been linked to excess androgen production.
Genes
Studies show that PCOS runs in families.It’s likely that many genes — not just one contribute to the condition.
Insulin resistance
Up to 70 percent of women with PCOS have insulin resistance.
Obesity is a major cause of insulin resistance. Both obesity and insulin resistance can increase risk for type 2 diabetes.
Inflammation
Women with PCOS often have increased levels of inflammation in their body. Being overweight can also contribute to inflammation. Studies have linked excess inflammation to higher androgen levels.
Three relevant points
- Hyperinsulinemia increases the formation of IGF-1 receptors and the secretion of LH at the hypophyseal level
- Inhibit the production of the sex hormone transport protein (SHBG), increases the free fraction of testosterone
- Insulin stimulates aromatase in granulosa cells, becoming androgens in estrogen, and having resistance to it, this is inhibited and androgens increase.
Thanks a lot José Fernando Díaz-Villanueva
But are there other contributors to PCOS other than insulin resistance because the points you mentioned are related to insulin resistance.
I have seen very typical PCOS phenotypes but with no insulin resistance or whatsoever, so can there be other factors leading to this PCOS phenotype?
Some genetically modified tendencies?
Some other diseases causing PCOS like patterns??
Regards
Dr Sikandar
Good day! Sorry for the delay, I had not received notification of your response. Another factor that influences PCOS is that there is a "genetic tendency" to produce a greater amount of luteinizing hormone in relation to follicle-stimulating hormone levels. There is even a laboratory value known as the LH/FSH ratio. I hope it helps you and you still receive my response in time for your projects. Greetings from Mexico.
- Badges
- Science topic
- Similar topics
- Geoscience
- Asia
- India