There is plenty of literature available on insulin resistance, however, it only adds to the confusion. I would like to know what the most appropriate method to quantify insulin resistance is.
The gold standard for measuring peripheral insulin sensitivity is the euglycemic hyperinsulinemic clamp.
thickening of the skin is attributed by collagen cross-linking and glycozylation but I suppose it is attributed by glycoseaminoglycans of the dermis and these molecules are responsible to insulin resistance
In what way glycosaminoglycans cause insulin resistance and what leads to an increase in their plasma concentration
There is a glycose depot in dermiş and insülin dosen't work on it. And insülin will increase. This is only hypothesis.
You can measure AGE (advanced glycation end products) and Maillard reaction of collagen with AGE reader a simple and useful tool for diabetic complications but not for glycosaminoglycans I suppose.
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