I found protein Side Chain Analogue (SCA) term in many papers on computational biochemistry, but never could find the actual definition of the term. I would appreciate definitions in your own words as well as helpful links.
David Oppenheimer
A side chain analog is an amino acid with the backbone (the amino group, the alpha carbon and its attached H, and the carboxy group) replaced by a hydrogen atom,
R
amino acid: 2HN—CH—COOH
SCA: R—H
where R is the side chain.
See this link for a listing of the common analogs used: http://md.chem.rug.nl/~periole/Publications_files/dejong-2012.pdf
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