Estimate Transition/Transversion Bias (ML) in MEGA
This option estimates the Transition/Transversion bias parameters ê, ê1, and ê2 using the Maximum Likelihood method. ê is used as a parameter of the Kimura Two-Parameter model of nucleotide evolution and some others, while ê1 and ê2 are used by the Tamura-Nei 93 model. This is applicable only to nucleotide data (coding or non-coding).