Secondly, looking into research into the variants for the MAOA (monoamine oxidase) and SERT (serotonin transporter) genes which have been empirically linked to increased aggression and increased anxiety/depression respectively. Boyce and Ellis's work on 'Biological sensitivity to context' (DOI: 10.1111/j.1467-8721.2008.00571.x ) offers the construct of 'orchid and dandelion children' showing how these gene variants make individuals more reactive and sensitive to their attachment environment magnifying it's impact. Thus with strong social support in childhood, they produce highly resilient well-regulated adults. However, with poor social support, they produce very dysregulated adults with high levels of psychopathology.

You might be interested in reading works by Connie Lillas (NeuroRelational Framework, and the work of Stuart Shanker.

You might be interested in Alan Schore's work, such as article 'Relational trauma and the developing right brain' (DOI: 10.1111/j.1749-6632.2009.04474.x) which explores the neurobiological effects of early attachment trauma.

Secondly, looking into research into the variants for the MAOA (monoamine oxidase) and SERT (serotonin transporter) genes which have been empirically linked to increased aggression and increased anxiety/depression respectively. Boyce and Ellis's work on 'Biological sensitivity to context' (DOI: 10.1111/j.1467-8721.2008.00571.x ) offers the construct of 'orchid and dandelion children' showing how these gene variants make individuals more reactive and sensitive to their attachment environment magnifying it's impact. Thus with strong social support in childhood, they produce highly resilient well-regulated adults. However, with poor social support, they produce very dysregulated adults with high levels of psychopathology.

Dear Robin and Paul

Thank you for the contributions,.

Especially the research of Boyce and Ellis will be interesting for me.

It seems that subcortical functions (amygdala, hippocampus, gyrus cinguli etc) will be senistive for deprivation and censequtive affective problems (selfregulation, top down control of the prefrontal cortex).

Greetings

Egon

I want to add some empirical data to the issues i mentioned before.

1: Krugers HJ, Joëls M. Long-lasting Consequences of Early Life Stress on Brain

Structure, Emotion and Cognition. Curr Top Behav Neurosci. 2014 May 27. [Epub

ahead of print] PubMed PMID: 24862989.

2: Wager TD, Gianaros PJ. The social brain, stress, and psychopathology. JAMA

Psychiatry. 2014 Jun 1;71(6):622-4. doi: 10.1001/jamapsychiatry.2014.288. PubMed

PMID: 24740473.

3: Bowes L, Jaffee SR. Biology, genes, and resilience: toward a multidisciplinary

approach. Trauma Violence Abuse. 2013 Jul;14(3):195-208. doi:

10.1177/1524838013487807. Epub 2013 May 6. Review. PubMed PMID: 23649831.

4: De Brito SA, Viding E, Sebastian CL, Kelly PA, Mechelli A, Maris H, McCrory

EJ. Reduced orbitofrontal and temporal grey matter in a community sample of

maltreated children. J Child Psychol Psychiatry. 2013 Jan;54(1):105-12. doi:

10.1111/j.1469-7610.2012.02597.x. Epub 2012 Aug 10. PubMed PMID: 22880630.

5: Ansell EB, Rando K, Tuit K, Guarnaccia J, Sinha R. Cumulative adversity and

smaller gray matter volume in medial prefrontal, anterior cingulate, and insula

regions. Biol Psychiatry. 2012 Jul 1;72(1):57-64. doi:

10.1016/j.biopsych.2011.11.022. Epub 2012 Jan 3. PubMed PMID: 22218286; PubMed

Central PMCID: PMC3391585.

6: van Harmelen AL, van Tol MJ, van der Wee NJ, Veltman DJ, Aleman A, Spinhoven

P, van Buchem MA, Zitman FG, Penninx BW, Elzinga BM. Reduced medial prefrontal

cortex volume in adults reporting childhood emotional maltreatment. Biol

Psychiatry. 2010 Nov 1;68(9):832-8. doi: 10.1016/j.biopsych.2010.06.011. Epub

2010 Aug 8. PubMed PMID: 20692648.

7: Woon FL, Hedges DW. Hippocampal and amygdala volumes in children and adults

with childhood maltreatment-related posttraumatic stress disorder: a

meta-analysis. Hippocampus. 2008;18(8):729-36. doi: 10.1002/hipo.20437. PubMed

PMID: 18446827.

greetings

Egon

To assume: I am sure that we have to be aware about different modulations of stressinduced neurobiological changes. What can you contribute to following issues.

1. The periode of individual development

2. Intensity and duration of stress (adevrsity and resilience factors)

3. Than the activity if the hypothalamic-hypophysic axis

4. synaptic rearrangements, and development of neuronal circuits

5. morphological changes of amygdaly, hippocampus, prefrontal cortext and the development oft he ability of top down control

6. an in general gene-enviroment, enviroment-gene interactions; and behavior-enviroment, enviroment-behavior interactions

greetings

Egon

Hello Egon Bachler!

Maybe it help You on?!:

The stronger the Trauma, the more difficult the Behaviour change as Self Regulation is one of Wilhelm Reich´s Basic Experience in the humanistic deep psychological Orgon Therapy / Psychiatry and in my holistic Trauma-Drug+Nourishment Assimilation Research and Self help - Group Experiences!

And as Basic Literature I offer for Self Regulation Research the Book from Wilhelm Reich: "Einbruch der sexuellen Zwangsmoral" about the South Sea-Trobiander, where Dr. Wilhelm Reich wrote about the sexual Self Regulation and about the Trauma and steps of the Break in into the patrriarchalic Morality and Society Hypothesis!!

Or the Book: "THE BIOELECTICAL INVESTIGATION OF SEXUALITY AND ANXIETY" in according to the Self Regulation Cell Reactions and Emotions , or "Christusmord", or Alexander Neals (as old Friend from Wilhelm Reich) Anti Authoritan "Summerhill School" "would be maybe as next interesting book for You?!!!

You´ll find them all surely in Amazon...

Maybe not in Your Library?!

With friendly Greeds

from:

VG

There is no empirical support for Reich's concept of Orgone in either medicine or the physical sciences.

I do not think self regulation is a unitary construct. I recommend this reference:

Handbook of Self-Regulation, Second Edition: Research, Theory, and Applications by Kathleen D. Vohs PhD and Roy F. Baumeister PhD (Jan 18, 2013)

Dear Liane,

Thank you for contributing this handbook. In oarticular I am intersteted in the construct "affectregulation" as it is used in he context of OPD working group (operationalized psychodynamic diagnostics)

greetings Egon

Dr baumeister has many books and articles in this field, even some of the chapers address neouroscience evidances for self regulation.

I recommend The Developing Mind: How Relationships and the Brain Interact to Shape Who We Are, Second Edition. By Daniel J. Siegel. Any of Dr. Siegel's work is invaluable. I may not be doing justice to his contributions and understandings yet I would say he depicts self regulation as the result of neuro integration. Self regulation is thus more than a top down phenomena in that it involves deep brain and left right hemisphere coherance. He is an advocate of mindfulness and "mindsight". As a clinician I have come to defer any cognitive approaches targeting self regulation until the client devlops some degree of somatic self awareness and ability to be in ones resilient zone (not neurologically overwhelmed or shut down).