What could be the possible reasons for high PDI value (~0.7) of gold nanoparticle which was observed through DLS ?

16 April 2023 1 9K Report

The gold nanoparticle was synthesised through Turkevich method. And also kindly suggest ways to work towards lowering the PDI index.

Kaushik Shandilya

Dear friend Adwaita Nair

The polydispersity index (PDI) is a measure of the size distribution of particles in a solution. A high PDI value indicates a broad size distribution with a wide range of particle sizes. There are several possible reasons for a high PDI value in gold nanoparticles synthesized through the Turkevich method, including:

Formation of multiple nucleation sites during synthesis, resulting in the formation of particles of different sizes.

Agglomeration of particles during synthesis or storage, resulting in larger particle sizes.

Incomplete reduction of gold ions, resulting in the formation of nanoparticles of different sizes.

To lower the PDI index and achieve a more uniform size distribution of gold nanoparticles, several approaches can be considered:

Optimization of the synthesis conditions, such as temperature, pH, and reaction time, to control the nucleation and growth of nanoparticles.

Addition of a stabilizing agent, such as citrate or polyvinylpyrrolidone (PVP), to prevent agglomeration and ensure a more uniform size distribution.

Purification of the nanoparticle solution to remove larger particles or aggregates.

Use of size-selection methods, such as centrifugation or filtration, to isolate nanoparticles of a specific size range.

There are several articles available in the literature that discuss the synthesis and characterization of gold nanoparticles, including their size distribution and PDI values. Some examples include:

"Synthesis and characterization of highly monodisperse gold nanoparticles" by H. J. Kim et al. (Journal of Materials Chemistry, 2004)

"Controlled synthesis of highly monodisperse gold nanoparticles with tuneable sizes" by Y. Xia et al. (Nanoscale, 2015)

"Polydispersity of nanoparticles: a review of experimental studies" by E. L. Tanczos et al. (Journal of Nanoparticle Research, 2018)

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