Abnormalities in the shape and morphology of the red blood cells will provide information in differential diagnosis. According to J. Ford (2013), interpretation of RBC morphologies is very important most especially when it comes to infants and children patients. Moreover, assessing RBC morphology plays a vital role for healthcare providers to be able to come up with the appropriate clinical follow up and medication required. By means of this, what are some conditions that will cause changes in the morphology of red blood cells?
Source: Ford - Wiley Online Library. (n.d.). https://onlinelibrary.wiley.com/doi/10.1111/ijlh.12082
Hemoglobinopthies are disorders that involves the hemoglobin protein and this causes an abnormal production and can change the structure of the hemoglobin. According to Biggers (2021), sickle cell anemia, thalassemia, hemoglobin C disease and hemoglobin S-C disease are some examples of hemoglobinopathies. Sickle cell anemia is a type of sickle cell disease where the blood cells forms sickle-shape and die too early. In thalassemia, your body has less hemoglobin than normal and it is caused when the body doesn’t make enough protein which is needed for red blood cells. Hemoglobin C disease is characterized by the target cell in the blood caused by a mutation in the beta-globin chain and the same target cell can be seen in Hemoglobin S-C disease where it is caused by a copy of the Hemoglobin S gene inherited from one parent and a hemoglobin C gene inherited from another.
Source: MediLexicon International. (n.d.). Red Blood Cell Disorders: Types, causes, and symptoms. Medical News Today. https://www.medicalnewstoday.com/articles/red-blood-cell-disorders-types-causes-and-symptoms#definition
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