I wonder what can happen to a vegetable oil (for example, olive oil or sunflower oil), if instead of bubbling it with a source rich in oxygen (for example 10% nitrogen : 90% oxygen), we bubble it with a source rich in nitrogen (for example 80% nitrogen : 20% oxygen). With a rich source of oxygen it is known that the "Criegee reaction" occurs and peroxides are released, but what can ocurr with nitrogen?
Thank you very much in advance!
Based on my experience, nothing is likely to happen because N2 is very inert. I bubble solvents all the time with N2.
Of course there are always exceptions in chemistry.
But if there is ozone gas too, what can happen? Ozone is pretty reactive and can oxidize N2, isn't it?
Yes, ozone will react with N2 producing nitrous oxide NO. Besides this, ozone will oxidize the plenty of carbon-carbon double bonds present in the unsaturated long chain fatty acids, generating various oxygenated compounds such as peroxides, hydro-peroxides, aldehydes, etc.
So... this can be harmful for human health? (for example applied on skin)
I agree Mr. Petruncio's answer, that Nitrogen will not make any changes in a vegetable oil. Oxygen will oxidize unsaturated bonds producing aldehydes and ketones but ozone much faster will affect the oils' chemical structure. I would say that such oxygenated compounds are harmful for human health and they are easily absorbed by skin.
I am bubbling ozone in a high concentration, following with an specific concentration of oxygen, and traces of nitrogen, but we have just realized about a disfunctional oxygen concentrator and for sure oil has been bubbled for long time with AIR and ozone in a low concentration (1 ppm). We all now that nitrogen is in a high ratio in air (around 80%), and that's why I am worried about a possible chemical process with nitrite or nitrosamines.
Carmen Mateescu the way we avoid the production of aldehydes and ketones in order to produce ozonides and peroxides in vegetable oil is the 'know-how' of the bussines I am working for (I am not allowed to talk about this) but I can absolutely prove you that those ozonated oils are non-citotoxic at all, and even are beneficial for human (and animal) health. The first who ozonized vegetable oils was Nikola Tesla. He was the first who patented the first ozone generator; and ozonetherapy kwnowledge has been increasing for the last century. Ozone activates the inmunological system through activation of cytokins ("...ozone readily dissolves in the fluid and, by reacting with unsaturated fatty acids and antioxidants, generates, within seconds, hydrogen peroxide and a variety of peroxidation compounds. Hydrogen peroxide, by diffusing into immune cells, activates the nuclear factor KB and allows the synthesis and release of immunoactive cytokines"), stimulates blood microcirculation in the skin, and of course ozone is a potent biocide that desinfect everything.
Thanks for your interesting comments
Here you can read more about it if you want :-)
Travagli, V., Zanardi, I., Valacchi, G., & Bocci, V. (2010). Ozone and ozonated oils in skin diseases: a review. Mediators of Inflammation, 2010.
Sakazaki, F., Kataoka, H., Okuno, T., Ueno, H., Semma, M., Ichikawa, A., & Nakamuro, K. (2007). Ozonated olive oil enhances the growth of granulation tissue in a mouse model of pressure ulcer. Ozone: Science and Engineering, 29(6), 503-507.
Valacchi, G., Fortino, V., & Bocci, V. (2005). The dual action of ozone on the skin. British Journal of Dermatology, 153(6), 1096-1100.
Bocci, V. (2007). The case for oxygen-ozonetherapy. British journal of biomedical science, 64(1), 44-49.
Valacchi, G., Lim, Y., Belmonte, G., Miracco, C., Zanardi, I., Bocci, V., & Travagli, V. (2011). Ozonated sesame oil enhances cutaneous wound healing in SKH1 mice. Wound Repair and Regeneration, 19(1), 107-115.
Geweely, N. S. (2006). Antifungal activity of ozonized olive oil (Oleozone). Int J Agri Biol, 8(5), 671-8.
Bocci, V., & Paulesu, L. (1990). Studies on the biological effects of ozone 1. Induction of interferon gamma on human leucocytes. Haematologica, 75(6), 510-515.
Paulesu, L., Luzzi, E., & Bocci, V. (1991). Studies on the biological effects of ozone: 2. Induction of tumor necrosis factor (TNF-alpha) on human leucocytes. Lymphokine and cytokine research, 10(5), 409-412.
Bocci, V., Luzzi, E., Corradeschi, F., Paulesu, L., & Di, A. S. (1993). Studies on the biological effects of ozone: 3. An attempt to define conditions for optimal induction of cytokines. Lymphokine and cytokine research, 12(2), 121-126.
Bocci, V., Luzzi, E., Corradeschi, F., Paulesu, L., Rossi, R., Cardaioli, E., & Di, P. S. (1993). Studies on the biological effects of ozone: 4. Cytokine production and glutathione levels in human erythrocytes. Journal of biological regulators and homeostatic agents, 7(4), 133-138.
Bocci, V., Luzzi, E., Corradeschi, F., & Paulesu, L. (1993). Studies on the biological effects of ozone: 5. Evaluation of immunological parameters and tolerability in normal volunteers receiving ambulatory autohaemotherapy. Biotherapy, 7(2), 83-90.
Bocci, V., Valacchi, G., Corradeschi, F., Aldinucci, C., Silvestri, S., Paccagnini, E., & Gerli, R. (1998). Studies on the biological effects of ozone: 7. Generation of reactive oxygen species (ROS) after exposure of human blood to ozone. Journal of biological regulators and homeostatic agents, 12(3), 67-75.
Günaydın, Y., Sevim, H., Tanyolaç, D., & Gürpınar, Ö. A. (2018). Ozonated Olive Oil with a High Peroxide Value for Topical Applications: In-Vitro Cytotoxicity Analysis with L929 Cells. Ozone: Science & Engineering, 40(1), 37-43. http://bit.ly/2mjvVfZ
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