What can be done if peaks are not coming proper for organic acids using LC-MS?

More Aishwarya Navnath Markad's questions See All

How can I maintain pH during solid state fermentation?

I am carrying out solid state fermentation using aspergillus niger to produce citric acid.But, I am not able to maintain the pH throughout the process.I want to set my pH between 3--4. What can be...

07 August 2019 702 5 View

What are the different types of low molecular weight organic acids produced by Aspergillus niger?

I want to know the names of low molecular organic acids which can be produced using Aspergillus niger.

05 June 2019 8,463 2 View

What is the reaction between citirc acid and zinc sulphate?

I have added 1g of citric to 4 g of zinc sulphate in the 100 ml of boric acid solution.Now, I want to know the actual reaction happening between them?

05 June 2019 3,506 1 View

What is the role of prescott salt in solid state fermentation?

In few papers,they have mentioned prescott salt is beneficial in solid state fermentation and in few papers they are saying its not..What is the key role of prescott salt and can it be uses...

10 November 2018 5,743 3 View

What type of contamination is observed in solid state fermentation experiment?

I am performing solid state fermentation experiment using aspergillus niger to produce citric acid using organic waste..I want to know which type of contamination is this? And what can be done to...

10 November 2018 3,454 3 View

How much fermented sample is to be taken for citric acid estimation?

I want estimate citric acid from fermented and unfermented sample using titration method.I want to know how much fermented sample can I take and how much do I need to dilute it to? And what should...

09 October 2018 3,712 1 View

How can we acheive the Ph range of 3-6 in a solid state fermentation in tray bioreactor?

I want to set the Ph of substrate consisting of organic waste and leaf litter.The procedure which I followed was: 1.I took 5 g of sample and added 50 ml of D.W. in it then I started adding...

09 October 2018 7,693 3 View

What are the good journals to publish botany(Plant field expt.) work?

Hello all, I want to publish a paper on effect ofa fertilizer on the growth of a particular plant. I want to know which are the good journals with good impact factor and also the probable amount...

07 August 2018 6,233 0 View

Why is methanol added to fermentation media?

I want to carry out SSF using various waste,I wanted to know that what is the reason behind adding methanol to the media? What advantage does it have?

05 June 2018 4,661 3 View

How to carry out a chelation reaction between citric acid and metal salts such as ZnSo4,CuSo4,FeSo4 and MgSo4?

I want to know the amount of citric acid and metal salts required for chelation and also which acid do I need to dissolve the individual metal salts.It would be good if anyone can help me with the...

02 March 2018 7,755 0 View

Chlorinated organic formation in odor control scrubbers using hypochlorite?

I'm involved in a study of odor control technologies for municipal wastewater treatment plant. One of the control options involves a chemical 2-stage (acid/alkaline) packed bed scrubber. The...

03 March 2021 3,661 2 View

What solvent can I used for Paal Knorr reaction between 6-amino hexanoic acid and 2.5 hexanedione?

I am try to make the Paal Knorr reaction between 2.5 hexnedione and 6-amino hexanoic acid, my problem is type of solvent to use, because 6-hexaminohexanoic acid is soluble in water but I am not...

02 March 2021 4,443 2 View

Ester cleavage conditions?

Hi all, I need to cleave the ester in Ethyl 2-amino-1H-imidazole-5-carboxylate to make the carboxylic acid and retrieve the product from solution to use in downstream applications of linking to...

01 March 2021 8,766 3 View

What is the state of the drug inside solid lipid nanoparticles (SLNs)?

I am a little confuse with the mechanism of solid lipid nanoparticles (SLNs). The main point of encapsulating drugs into SLNs is because some drugs have low solubility in water. Therefore, SLNs...

01 March 2021 3,703 3 View

Is CD44 degraded in lysosome together with hyaluronan after CD44 mediated endocytosis of hyaluronic acid?

Also when RHAMM binds hyaluronic acid, they get internalized, will RHAMM also be degraded? Or both CD44 and RHAMM will be transferred back to the cell membrane? Asking for breast cancer cell line...

01 March 2021 8,169 2 View

How to remove DCU and HOBT from my reaction?

I am doing a acid and a chiral amino alcohol reaction using DCC and HOBT in DCM or THF? Can anyone suggest me how to remove DCU and HOBT from a reaction mixture??

28 February 2021 2,153 1 View

What is the most common number of epitopes in an multi-epitope Vaccine?

hi everyone, I'm interested in the field of vaccine design specifically multi-epitope cancer vaccines , I want to know if there is a minimum and maximum number of epitopes we could use in a...

27 February 2021 3,882 3 View

I want to performe MALDI-TOF MS for bacterial identification, I would appreciate it if anyone can tell me the matrix solution preparation protocol ?

based on what I've studied on multiple papers, for peptide and protein identification Alpha-cyano-4-hydroxycinnamic acid (CHCA) is an appropriate matrix to use, I also know that the CHCA powder...

26 February 2021 6,799 3 View

How to increase solubility of Poly acrylic acid in Dioxane solvent?

I am working with Polyacrylic acid (100.000Da) and instead of water, I need to use another solvent (dioxane) to dissolve PAA. However, because of the high molecular weight, it's quite hard to...

25 February 2021 2,225 5 View

How can we theoretically calculate Elemental analysis(percentage) of atoms in covalent organic framework?

For example in one research article the Elemental analysis values of COF-TpPa-1 ( Triformylphloroglucinol (Tp) (63 mg, 0.3 mmol), Paraphenylenediamine (Pa-1) (48 mg, 0.45 mmol) are as follows...

24 February 2021 1,265 6 View

Boredi Silas Chidi

Please check the system manual. There are many troubleshooting tips there

Sharmin Suraiya

N.T. Markad

You can see the following research articles.

Anand Gupta

You can try organic modifier in LC improvisation by adding TFA (Triflouro Acetic acid) which may give you better symmetry and resolution in your LCMS.

But, you have to optimize the concentration of TFA as critical parameter

Thank You