I want to know about the toxicity risks associated with Janus nanoparticles. I think, because of the dual nature on surface (unlike quantum dots as they have core and shell characteristics), they may have toxicity issues. Is it so?
I agree with the previous answer, also I want to comment that the toxicity is related to the nature and surface properties, reactivity. and also we must consider the interactions in biological media that calling for a new entity with new responses to be assessed. The toxicity is something that should be evaluated for each new nanomaterial, and must consider behavior at the nano-bio interface, there are approaches that can provide insights into toxic behavior, but behavior is not all, models of toxicity and parameters to consider are determinants. Depending on what you want to evaluate, you can also try biocompatiilizar nanomaterials, obtaining new approaches
ya i agree.. Interaction with bio system determines the toxicity levels. But I think, bcoz of its dual nature on surface, it may increase the risks!! The plasma protein or cellular protein which goes fine with one material of Janus particle may not be compatible for other material on its surface. I am afraid that it may lead to alteration of protein or vice versa. Thus it may cause some unknown toxic effects!!
We can make them bio compatible by coating with biomolecules. But there the uniqueness of janus particle gets lost !! Is that so?
Thank you sir!!
I am not using them, but wanted to know about the interaction mechanisms and nature of those particles.
I agree with Robin but I just want to add : if you use nanoparticles with two surface functionalizations especially two different biomolecules, maybe you can have interaction of the two separately maybe with a supplementary effect, a synergistic effect, this could be an important thing especially in vivo
- Badges
- Science topic
- Similar topics
- Chemistry
- Nanotechnology
- Nanoparticle Research