NLM's PubMed has many publications of possible interest to you. Attached are links to two examples from PubMed on "Liver fluke infection and cholangiocarcinoma: a review" and "A prospective view of animal and human Fasciolosis."
https://www.ncbi.nlm.nih.gov/pubmed/27718017
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5053257/
hello dear
Liver fluke infection and cholangiocarcinoma
https://patient.info/doctor/fasciola-hepatica
Dear Fatima
Their were multiple effects of Fasciola hepatica, which related to their size, movement, west product, attachment in the lumen of ducts, reproduce and release ova, feeding.. All these above cause toxic effect and this also depend on the amount of infestation and the immune response..
Thank you and best regards
Hi
Show this article I hope benefit you
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3655246/
Dear,
The first pathogenic action after crossing the glison capsule at 48 Hs post-infection by cercariae or metacercariae is the destruction of hepatic tissue by the ingestion of hepatocytes and blood during the first 30 days. Then the fasciolómulos already lodged in the bile ducts gives everything associated with cholangitis and fibrosis of them.
see this link
https://en.wikipedia.org/wiki/Fasciolosis
Dear F. Mohammad
Both F. hepatica and F. gigantica can cause fasciolosis. Human symptoms vary depending on if the disease is chronic or acute. During the acute phase, the immature worms begin penetrating the gut, causing symptoms of fever, nausea, swollen liver, skin rashes and extreme abdominal pain.
The chronic phase occurs when the worms mature in the bile duct, and can cause symptoms of intermittent pain, jaundice and anemia. In cattle and sheep, classic signs of fasciolosis include persistent diarrhea, chronic weight loss, anemia and reduced milk production. Some remain asymptomatic. F. hepatica can cause sudden death in both sheep and cattle, due to internal hemorrhaging and liver damage
Fasciola hepatica secretes cathepsin L proteases that facilitate the penetration of the parasite through the tissues of its host, and also participate in functions such as feeding and immune evasion. The major proteases, cathepsin L1 (FheCL1) and cathepsin L2 (FheCL2) are members of a lineage that gave rise to the human cathepsin Ls, Ks and Ss, but while they exhibit similarities in their substrate specificities to these enzymes they differ in having a wider pH range for activity and an enhanced stability at neutral pH. There are presently 13 Fasciola cathepsin L cDNAs deposited in the public databases representing a gene family of at least seven distinct members, although the temporal and spatial expression of each of these members in the developmental stage of F. hepatica remains unclear.
The pathogenic effect depending on the number of flukes inside host and each fluke with their activity, west product, reproduce, released ova. All these cause the pathogenic, furthermore, the species hepatica or gigentica make another action because of their different in size.
Fasciolosis is a parasitic worm infection caused by the common liver fluke Fasciola hepatica as well as by Fasciola gigantica. The disease is a plant-borne trematode zoonosis, and is classified as a neglected tropical disease (NTD). It affects humans, but its main host is ruminants such as cattle and sheep. The disease progresses through four distinct phases; an initial incubation phase of between a few days up to three months with little or no symptoms; an invasive or acute phase which may manifest with: fever, malaise, abdominal pain, gastrointestinal symptoms, urticaria, anemia, jaundice, and respiratory symptoms. The disease later progresses to a latent phase with less symptoms and ultimately into a chronic or obstructive phase months to years later. the chronic state the disease causes inflammation of the bile ducts, gall bladder and may cause gall stones as well as fibrosis. While chronic inflammation is connected to increased cancer rates, it is unclear whether fasciolosis is associated with increased cancer risk. For more details , you can visit the following link:
https://en.wikipedia.org/wiki/Fasciolosis
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