Enzymes from the lyase, ligase, and hydrolase classes have the ability to catalyze carbon-carbon bond formation. Likewise, I want to know about specific enzymes (like Transglutaminases) or class of enzymes which plays part in iso-peptide bond formation. Answers would be highly appreciate
An example is the muramyl ligase MurD in the biosynthetic pathway for synthesis of bacterial peptidoglycan. This enzyme catalyzes addition of an isopeptide bond between UDP-MurNAc-alanine and D-glutamate.
Check out this Wikipedia article on isopeptide bonds.
https://en.wikipedia.org/wiki/Isopeptide_bond
Isopeptide bonds can be formed enzymatically, or they can occur spontaneously between neighboring amino acids. Enzyme-catalyzed isopeptide bond formation involves the activation of the carboxyl group via an acyl-enzyme intermediate, followed by nucleophilic attack by a free amino group. Another very good example could be found here: Article An Unusual Mechanism of Isopeptide Bond Formation Attaches t...
https://www.nature.com/articles/srep39291- Badges
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