Thank you Prof. Hee Sun Kang, i think this is one way to look into - among many other reasons, attributed to low performance of oral vaccines in low income countries. Can you be specific what kind of cultural beliefs have you come across that discourages people from taking oral vaccines? I am interested to know your thoughts on it.
Also malnutrition that goes with some degree of anergy as well as enter overused. But these are all scientific guesses which make sense anyway. However, we need well designed studies to elucidate these issues. Have also noted that response to injectable vaccines are is sometimes lower in developing countries too (though not as low as oral vaccines)?