Sepsis is not physiological state. So there is no physiological concentrations of coagulation proteins in this condition. Concentrations of proteins depend on the disease severity. Why not try to examine samples from patients suffering from sepsis?

I´m sorry about the ambiguous question. I am interested in concentrations of these plasma protreins that can be achieved during a sepsis or a polytrauma (for example that have ever been measured). As in vitro assays often reveal unspecific effects due to the use of very high concentrations (in enzymes and inhibitors) and thereby do not reflect the clinical state, I assume that this is relevant to determine wether a protease activity seen in vitro has an in vivo relevance or not. Even more striking is the time course in of protein level that might vary very quickly (due to half life and the proteins cleavage) in polytrauma or sepsis.

I was wondering if there was any literature where these factors where measured during polytrauma or sepsis? Thanks again for your ideas