To overcome the metabolism effect, we try two ways first medicinal chemistry modification of parent drug or application of pharmaceutical dosage form.

Thanks for your response.. but please let me know which are some of the drugs having such problems

Resveratrol is a typical example. it has been shown to have cancer chemoprevention potential, but its bioavailability is suffered due to multiple reasons, including low stability, increased oxidation, poor solubility and high uptake by hepatic cells.

This is a most useful answer.. please give some references for the poor bioavailability of resveratrol

You may find useful information here: Article Resveratrol in cancer management: Where are we and where we ...

Curcumin

Please explain.. curcumin is having improved performance in many nanoformulations

Yes nanoformulations improve bioavailability but as such has low solubility.

Even Neem, garlic oil and green tea have anticancer properties.

Please discuss some phytochemicals which are not yet showed good performance with nanoformulations

Natural products have potential anticancer or antiviral but most of them destroyed by metaboloic pathway or low biavilability we try nanotechnology with water insoluble compounds or extracts and they have high results with stable form.

Give some examples.. any issue with toxicity of nanoformulations we used with drug? What are the phytochemicals that are still difficult to administer even with nanoformulations?

Many marine water extracts have been formulated as. Gold caped or silver caped nanoparticles with great pharmacological diversity as antimicrobial, antiviral and anticancer.

very good information.. but how can we remove the gold and silver nanoparticles after drug release.. what about their toxicity in body?

Nanoparticles decreased required dose and gold particle have theraputic effects the formed nanoparticles have no toxicity or minimal toxicity avoiding to teqnic used

Article Lead Phytochemicals for Anticancer Drug Development

Thanks@Mehdi Shakibaei