This is, indeed, a very important question that have been asked on Quora. It is sad there is only one answer. I believe that the next years will bring very important discoveries now that we have identified the action of Microglias. What is you opinion on this point ?
https://www.quora.com/What-are-the-most-promising-experimental-treatments-of-chronic-pain
1. Ren, K., & Dubner, R. (2008). Neuron-glia crosstalk gets serious: role in pain hypersensitivity. Current opinion in anaesthesiology, 21(5), 570.
2. Hossain, M.Z.; Unno, S.; Ando, H.; Masuda, Y.; Kitagawa, J. Neuron–Glia Crosstalk and Neuropathic Pain: Involvement in the Modulation of Motor Activity in the Orofacial Region. Int. J. Mol. Sci. 2017, 18, 2051.
Anticonvulsants (pregabalin) in low doses for neuropathic pain.
I believe, the answer is in including mechanical diagnostic procedures into the medical diagnostic model to rule in/ out a combined mechanism of pain (chemical/ mechanical). The pain management approach would customize use of medications and specific pain reducing movements or positions, which are reproducible by the patient at will.
Please search for "directional preference" and " centralization" . The neuropathic pain may be intermittent or constant, also subject to testing for a mechanical origin. Thank you.
i AM WORKING ON INTERNAL ISOLATION OF POACHES/ VOLUMES GENERATING PAIN NEAR BONES.
USING BETWEEN 70 TO 95% OF WATER
NOT USING AINS FOR SIMPLE CASES
I WILL SAY WE REACH A REDUCTION OF PAIN IN 75% OF CASES.. TESTS ON 30 CASES ON THE DATE OF END JUNE 20019 , MOST AFTER CANCER OPERATIONS AND SPORT ACCIDENTS.
Chronic pain consistes many components. Therefore we should use complex therapy for it treatment. I use my Empatho-technique method with complex therapy and without it. I created Empatho-techique specially for chronic pain of different origion.
Good luck :)
Chronic pain may reprogram the way genes work in the immune system. The findings could open new avenues to diagnosing and treating chronic pain in humans, the researchers suggest, as some of the genes found to be marked by chronic pain could also represent new targets for pain medications.
Read this our dated publication:
Chapter Genetics and Immunity of Pain
Dear Francesco Calendese
My research skips the gene pain factor. I works on different means and it gives actually some results on pain release treatment.
Do you perform tests on pain?
After signature of secrecy agreement, you could test my new method that does not involve pharmaceutical means such as AINS ; in 75% of the cases, I gusss
kind regards
Jean De from France
Dear Jean Debetencourt ,
personally I firmly believe that changes in DNA could partly explain the variation in individual differences in pain. Various genes encoding for receptors are now known to play a major role in the sensitivity, perception and expression of pain.
Dear Fransesco
yes you are right , that' one step of the stair of pain
but it is not enough
I am working on other steps but your step merits studies to predict pain occurence and intensity
with my kind regards
Jean
Drug and non drug strategies including integrative treatment show on the clinical field main improvements .
in background the focus of all vicous circles involved from the pathysiology to metabolism ,gut brain axis and epigenetics factors .....allowed multimodal strategies reducing doses, tolerance and improving all parameters of the alterated Chronobiology
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