AMPs
Sodium channel blockers
Potassium channel blockers
Anionic peptides
Hypotensins
AMPs
Sodium channel blockers
Potassium channel blockers
Anionic peptides
Hypotensins
Rates,B., Ferraz,K.K., Borges,M.H., Richardson, M., De Lima,M.E. &A.M. Pimenta 2008. Tityus serrulatus venom peptidomics: assessing venom peptide diversity. Toxicon 52(5):611–618.
http://www.researchgate.net/publication/23185903_Tityus_serrulatus_venom_peptidomics_assessing_venom_peptide_diversity
Abstract
MALDI-TOF-TOF and de novo sequencing were employed to assess the Tityus serrulatus venom peptide diversity. Previous works has shown the cornucopia of molecular masses, ranging from 800 to 3000Da, present in the venom from this and other scorpions species. This work reports the identification/sequencing of several of these peptides. The majority of the peptides found were fragments of larger venom toxins. For instance, 28 peptides could be identified as fragments from Pape proteins, 10 peptides corresponded to N-terminal fragments of the TsK beta (scorpine-like) toxin and fragments of potassium channel toxins (other than the k-beta) were sequenced as well. N-terminal fragments from the T. serrulatus hypotensins-I and II and a novel hypotensin-like peptide could also be found. This work also reports the sequencing of novel peptides without sequence similarities to other known molecules.
Article Tityus serrulatus venom peptidomics: Assessing venom peptide diversity
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