Can I use EDPVR to characterize LV compliance if I get that EDPVR from PV loop at steady state, without loading change? What are the limitation of this indice?
Yes, you can estimate LV compliance from single P-V loop at steady state. The limitation Is it’s accuracy Issue.
Thank your for your response Liang Zhong . What could limitate the accuracy? Is it dependant of charge conditions?
Hi Charlotte,
I assume you're measuring PV-loops in animals, perhaps rats or mice?
I think in this case it's perfectly acceptable to estimate the EDPVR using the single-beat method as mentioned above, especially if you want to maintain a closed-chest preparation. There are several methods available, depending on your model, catheter etc. Given the single-beat method is most commonly used in the clinical setting, I don't think it's necessarily less accurate.
Moreover, performing consistent load reductions in the same animal and between animals requires some skill!
I hope this helps you and good luck!!
- Badges
- Science topic
- Similar topics
- Biological Science
- Physiology
- Physiological Processes
- Stress