- Do they require special software to process?
- Do they require a specialized board for the NMR to do the Chirp pulses?
- Are there any vendors who have distributed these pulse sequences?
- What is the sensitivity gain/loss with these experiments?
- Although the theory states that you get enough information in 1 transient, is it possible to collect several times and sum up the information to improve S/N?
Hello Clemens,
Thanks for your answer, I have indeed looked at the ASAP experiments and am pretty fascinated by them. I am indeed running on a Bruker instrument, so knowing the pulse sequences for sf and b_ are very helpful as well.
What are the reasons that these are applied mainly to proteins? I have noticed a number of selective experiments aimed at acquiring signals only for the peptide backbone, but the principal should still work when applied to small molecules, or am I getting these confused with other acquisitions? Also, after reviewing the pulse sequences we have, I am noticing that the majority of pulse sequences (b_) are 3D, which is a wonderful use of the time savings.
Do Bruker instruments have an ASAP pulse sequence in the instrument library, or is this an example of a pulse sequence that I should obtain from the author?
Once again, Thank you very much!
I am super interested in seeing if this works for our application. It seems like quite an advancement, and if the sensitivity loss is acceptable, I am hopeful we will adopt it.
Thanks for all your help,
Joseph
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